Effectiveness of hemodialysis in a case of severe valproate overdose

JOURNAL TITLE: Indian Journal of Critical Care Medicine

Author
1. Deepak Sehrawat
2. Prashant Nasa
ISSN
0972-5229
DOI
10.4103/0972-5229.83020
Volume
15
Issue
2
Publishing Year
2011
Pages
3
Author Affiliations
    1. Department of Medical ICU, Indraprastha Apollo Hospital, New Delhi, India
    1. Department of Medical ICU, Indraprastha Apollo Hospital, New Delhi, India
  • Article keywords
    Anti-coma management, high-flux hemodialysis, hyperammonemia, valproate overdose

    Abstract

    A case of severe sodium valproate overdose is presented in which medicinal management failed to reverse coma of the patient. High-flux hemodialysis was then used to eliminate sodium valproate. This case demonstrated the effectiveness of hemodialysis in not only decreasing valproate levels very rapidly but also as an effective anti-coma management.

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