Clinical and laboratory features associated with acute kidney injury in severe malaria

JOURNAL TITLE: Indian Journal of Critical Care Medicine

Author
1. Hiren Anghan
2. Prayas Sethi
3. Sandeep Mahajan
ISSN
0972-5229
DOI
10.4103/ijccm.IJCCM_468_17
Volume
22
Issue
10
Publishing Year
2018
Pages
5
Author Affiliations
    1. All India Institute of Medical Sciences, New Delhi
    2. All India Institute of Medical Sciences, New Delhi, India
    1. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    1. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
  • Article keywords
    Acute kidney injury, critically ill, severe malaria

    Abstract

    Introduction: Critically ill severe malaria constitutes one of the major hospital admissions in Indian setting. Clinical studies identifying the factors associated with acute kidney injury (AKI) in malaria are lacking. This study aimed to identify these factors. Methods: This prospective observational study was conducted in a tertiary care center of North India. All adult patients with severe malaria were studied during 2012–2014. Results: The study included 79 patients and AKI was observed in 36 patients. Of these 79 patients, 52.7% were Plasmodium falciparum positive and 47.2% were Plasmodium vivax positive. In AKI patients, thrombocytopenia and jaundice were the most common other complications seen. Among P. vivax malarial patients, 17 (36%) patients had AKI. Features associated with AKI among patients admitted with P. vivax malaria were as follows: tachycardia (adjusted relative risk [RR]: 3.9; 95% confidence interval [CI]: 1.1–13.7), direct hyperbilirubinemia (adjusted RR: 4.7; 95% CI: 1.4–15.2), anemia (adjusted RR: 6; 95% CI: 1.7–22.4), and sepsis (adjusted RR: 3.3; 95% CI: 1.1–13.7). The presence of tachycardia, acidosis, cerebral malaria, acute respiratory distress syndrome/acute lung injury, hypotensive shock, and poor Glasgow Coma Scale were associated with higher mortality in patients with AKI. Patients who required mechanical ventilation and/or vasopressor support had higher mortality. Conclusion: P. vivax is an important cause of severe malaria with AKI in our setting. Various other clinical features are associated with AKI and related mortality.

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