Establishing the diagnosis of a disease that can impact the vision and life of a patient (such as keratoconus) is a moment of great responsibility. Therefore, ophthalmology has been looking for to integrate the results provided by the most recent high-tech equipment to try to develop a Super Index capable of determining the presence or absence of this disease with the lowest chance of error. The bad side of this strategy is the high cost of performing multiple and sophisticated exams. However, in moderate and advanced cases, the use of simple and cheap exams may be enough to diagnose keratoconus accurately. Therefore, a multimodal analysis based only on topography and pachymetry was suggested to determine if the disease exists or not, with good sensitivity and specificity. In this way, few patients (especially those with early stages of the disease) will need to be referred for a more detailed evaluation through expensive tests.