Therapy Targeting Stem Cell in Patients with Decompensated Cirrhosis of Liver in a Tertiary Treatment Care Center of Bangladesh

JOURNAL TITLE: Euroasian journal of hepato-gastroenterology

Author
1. Ahmed L Moben
2. Mohammad A Alam
3. Mohammad H Uddin
4. Sheikh MN Alam
ISSN
2231-5047
DOI
10.5005/jp-journals-10018-1229
Volume
7
Issue
1
Publishing Year
2017
Pages
3
Author Affiliations
    1. Forum for the Study of the Liver, Dhaka, Bangladesh
    1. Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Medicine, Kurmitola General Hospital, Dhaka, Bangladesh
    1. Department of Hepatology, Dhaka Medical College, Dhaka, Bangladesh
  • Article keywords

    Abstract

    Introduction

    Decompensated cirrhosis is associated with significantly high mortality resulting from hepatic failure, and liver transplantation seems to be the only viable indication for its management. The objective of this study is to assess if granulocyte colony-stimulating factor (G-CSF), a stimulatory of stem cell in vivo, may be of any benefit for patients with decompensated cirrhosis of liver.

    Materials and methods

    Seventeen consecutive patients with decompensated cirrhosis of liver were recruited in this prospective study. They received injection of G-CSF (30 IU) over a period of 6 weeks (12 injections) in addition to standard of care.

    Results

    Patients were followed up at the end of treatment and at 12 weeks of treatment. Treatment was well tolerated, and no significant adverse event was recorded in any patient. Fifteen out of 17 (88%) patients were alive at last follow-up. Although serum bilirubin, albumin, and prothrombin time improved in some patients, statistically significant improvement of Child–Pugh score could not be documented.

    Conclusion

    The study establishes the safety of G-CSF therapy in patients with decompensated cirrhosis of liver. Besides, such therapy may also have survival benefit, although long-term follow-up is needed to assess its real utility in clinical perspectives.

    How to cite this article

    Al Mahtab M, Alam SMN, Moben AL, Raihan R, Alam MA, Rahim MA, Uddin MH, Akbar SMF. Therapy Targeting Stem Cell in Patients with Decompensated Cirrhosis of Liver in a Tertiary Treatment Care Center of Bangladesh. Euroasian J Hepato-Gastroenterol 2017;7(1):113-115.

    Source of support

    The study was partially supported by a grant from Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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