Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma

JOURNAL TITLE: Euroasian journal of hepato-gastroenterology

Author
1. Salimur Rahman
2. Muhammad M Hussain
3. Mobin Khan
4. Shahidul Islam
5. Nooruddin Ahmed
ISSN
2231-5047
DOI
10.5005/jp-journals-10018-1228
Volume
7
Issue
1
Publishing Year
2017
Pages
2
Author Affiliations
    1. Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Hepatology, Bangabandhu Shiekh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Oncology Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
    1. Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Article keywords

    Abstract

    Introduction

    Hepatitis B virus (HBV) infection is an established cause of hepatocellular carcinoma (HCC) and is associated with poor prognosis. High HBV deoxyribonucleic acid (DNA) load has been identified in HCC and hepatitis B surface antigen-positive patients.

    Materials and methods

    This study was done in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from January 2006 to December 2007. Thirty patients with HBV infection-related HCC were enrolled. Another 30 patients with HBV-related liver diseases without HCC were analyzed as controls.

    Results

    The HCC patients had a high viral load (>105 copies/mL), while all of the controls had low (<105 copies/mL) viral load.

    Conclusion

    It seems that patients with HCC bear high HBV DNA loads in Bangladesh, but the causes underlying this remain to be resolved.

    How to cite this article

    Hussain MM, Al Mahtab M, Islam S, Ahmed N, Rahman S, Khan M. Relationship between Hepatitis B Viral Deoxyribonucleic Acid Load and Hepatocellular Carcinoma. Euroasian J Hepato-Gastroenterol 2017;7(1):111-112.

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