Aim: Acute pancreatitis (AP) is an inflammatory disorder, the incidence of which has been increasing
over recent years. Mean platelet volume (MPV) is an index of platelet activation and influenced by
inflammation. The objective of the present study is to assess whether MPV would be convenient
parameters for predictor factor of patients with AP.
Materials and methods: A total of 140 AP patients (male/female: 63/77) and 70 healthy subjects
(male/female: 23/47) were enrolled in this study. The following data were extracted from the hospital
medical records, including age, sex, platelet count, MPV, were recorded at the time of admission
and as well as at the 1st day of remission of the disease.
Results: Mean platelet volume levels at onset and remission of AP were 7.8 ± 1.6 and 7.7 ± 0.9 respectively,
and there was no statistically significant difference between these groups. Platelet count at onset and
remission of AP and control subjects was 203 ± 74 × 103/μl, 234 ± 76 × 103/μl and 251 ± 87 × 103/μl,
respectively, and there was statistically significant difference between these groups. Platelet count
at onset and remission of AP was statistically lower than control subjects.
Conclusion: Some studies in literature suggest that MPV might be a useful parameter to be used as
an indicator for AP and a prognostic factor for AP, but, in this study, it was revealed that MPV values
do not change at AP compared with controls. Therefore, further prospective studies investigating the
factors affecting the platelet size are required to determine whether MPV has a clinical implication
and for predictor value of patients with AP.