Rheumatoid arthritis (RA) is a chronic inflammatory condition, usually affecting females three times more than the males. The peak age of onset is in the childbearing age-group i.e., 19–44 years. Females with RA face difficulties at the time of conception, during pregnancy, and in the lactation period. Certain drugs used for the management of RA have deleterious effects on pregnancy outcomes. Thus, it is increasingly becoming a topic of concern as well as discussion for healthcare providers and medical professionals to guide the affected females in planning for pregnancy, safer pharmacotherapies, and to overcome the phobia related with their disease effects.