Introduction: Age determination is essential for human being, because of its social, legal, and judicial involvement. The tooth represents an excellent medicolegal tool for age assessment through its growth, biological behavior, and aging. The aim of this study was to find a correlation between pulp volume dimension and chronological age (AC) using the Drusini's method. Materials and methods: A total of 150 panoramic radiographs of Senegalese people aged 10–44 years were included in this study. Drusini's method was used to estimate age. The collected data were analyzed with R software version 3.6.1. Student's t-test was used for mean comparisons with a significance threshold of 0.01. Results: The average premolar height of the coronal pulp cavity (CPCH) value was 2.64 mm in men and 2.28 mm in women. The mean molar toothcoronal index—molar (TCI-M1) value was 41.59–4.04 in women and 38.78 (4.87) in men. The result of the Pearson's correlation test shows a negative correlation of –0.899, significant between molar TCI and AC (p < 0.001). A strong correlation was also noted between AC and premolar TCI (p < 0.001). Conclusion: Drusini et al.'s method could be a useful tool for age determination in a Senegalese population.