Colorectal cancer manifests usually with a change in bowel habit or a bleeding per rectum. Much less commonly, colorectal cancer may present as part of paraneoplastic syndrome. Paraneoplastic syndromes may help in the timely diagnosis of the case.
The authors describe a case report of a 60-year-old woman with a hyperpigmented skin rash and proximal muscle weakness who was subsequently diagnosed with rectal carcinoma in the setting of progressive muscle weakness.