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Chapter-09 Organisation and Structure of DNA

BOOK TITLE: Self Assessment and Review of Biochemistry

Author
1. Perumcheril Rebecca James
ISBN
9789386322401
DOI
10.5005/jp/books/14226_10
Edition
3/e
Publishing Year
2018
Pages
11
Author Affiliations
1. Government Medical College, Calicut, Kerala, India, Government Medical College, Kozhikode, Kerala, India
Chapter keywords
Deoxyribonucleic acid, DNA, Watson-Crick model, A-DNA, B-DNA, C-DNA, D-DNA, E-DNA, Z-DNA, central dogma, molecular biology

Abstract

This chapter seeks to familiarize the readers with organisation and structure of DNA. Watson-Crick and Wilkins to propose a model of a DNA in 1953 based on the X-ray diffraction photographs of DNA taken by Rosalind Franklin. Salient features of Watson-Crick Model of DNA are right-handed double stranded DNA helix, base pairing rule, two strands are antiparallel, hydrogen bonding and grooves of the DNA. Six types of DNA are A-DNA, B-DNA, C-DNA, D-DNA, E-DNA, and Z-DNA which are discussed briefly in this chapter. Triple-stranded DNA is generated by the hydrogen bonding of a third strand into the major groove of B-DNA. This chapter also covers the supercoiling of DNA and the central dogma of molecular biology. At the end of the chapter, multiple choice questions are also given along with their explanatory answers.

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