Local anesthetics are most commonly used in regional anesthesia procedures. First and foremost, consent is necessary for the procedure. If the patient does not consent, the procedure should not be performed. For neuraxial approaches, the practitioner should decide if the procedure will require a short duration or long duration blockade. Chloroprocaine and lidocaine are the best agents for short procedures, while bupivacaine and tetracaine are commonly used for longer procedures. Treatment of cardiovascular instability and/or collapse as a result of local anesthetic toxicity is possible utilizing a lipid rescue technique after calling for help, appropriately managing the airway, and initiating emergency protocols to stabilize the patient.