Knee pain is a common presenting complaint in patients of all ages. It is present in approximately 20–25% of the general population and commonly occurs secondary to trauma, sport-related activities, overuse syndromes, and degenerative changes. Musculoskeletal-related injuries account for nearly 21% of visits to primary care office, with knee pain ranking second only to low back pain in that category. The most common etiology of knee pain are strains and sprains (42%), osteoarthritis (OA) (34%), meniscus (9%), collateral ligament (7%), cruciate ligament (4%), gout (2%), fracture (1.2%), rheumatoid arthritis (0.5%), infectious arthritis (0.3%), and pseudogout (0.2%). Treatment is directed to the underlying diagnosis. In general, conservative therapy consisting of nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, modalities, bracing/casting, immobilization, and injections (steroid, anesthetic, and/or hyaluronic acid) are indicated.