This chapter gives an overview on orofacial pain. Orofacial pain of myofascial origin presents as persistent, deep, aching, poorly localized pain that involves facial muscles, often the muscles of mastication. The diagnosis is based on the presence of trigger points that reproduce the pain. Pharmacologic treatment of orofacial pain of neurogenic origin is similar to that for other neuropathic pain states. Anticonvulsants, antidepressants, opioids, and in some cases muscle relaxants (baclofen) are the most common medications used. Diagnostic and therapeutic nerve blocks are of limited utility. A well-illustrated flowchart on patient with orofacial pain is also presented in this chapter, which is very helpful for readers or students.