Continuous peripheral nerve block is indicated for expected moderate to severe pain lasting longer than 24 hours. These procedures are commonly used in the perioperative period; and, their use has been documented in the treatment of intractable hiccups, vasospasm of Raynaud’s disease, peripheral embolism, chronic regional pain syndrome (CRPS), intractable phantom limb pain, terminal cancer, and trigeminal neuralgia. Continuous interscalene, infraclavicular, or axillary techniques can provide effective analgesia for upper extremity pain. These techniques are commonly utilized to provide prolonged, postoperative analgesia. The continuous block of the femoral and/or sciatic nerves or lumbar plexus is commonly utilized for the management of lower extremity pain. A sciatic nerve catheter can be placed utilizing parasacral, lateral, and popliteal approaches.