Withdrawal syndrome is characterized by a constellation of constitutional symptoms, autonomic instability, thermoregulatory derangements, and other commonly reported signs and symptoms. In the pediatric population, the most common symptoms are diarrhea, vomiting, sweating, and fever. Reports indicate that opioid withdrawal occurred in 57% of neonates and 44% of children aged 2 weeks to 21 years after 5 days of continuous or scheduled opioid therapy in the intensive care unit (ICU). Risk of withdrawal is reduced when patients are either weaned off opioids or are given opioid doses less frequently. The literature indicates that the occurrence of withdrawal syndrome correlates with the speed of the opioid weaning process.