The field of regenerative medicine has gained more popularity as a possible treatment strategy for soft tissue and joint injuries and may be more advantageous for these particular types of chronic pain conditions. Two conditions with a large amount of evidence supporting the use of regenerative medicine are chronic tendinopathies and degenerative conditions involving cartilage and bone, specifically osteoarthritis. Regenerative medicine can be broken into three categories following as prolotherapy, platelet-rich plasma (PRP) injections, and stem cell therapy. Prolotherapy is a technique of injecting an irritant, typically a hyperosmolar dextrose solution into the area of pain. The use of injectable stem cells (SCs) in chronic pain caused by soft tissue and joint injuries remains controversial. Both mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) are utilized in regenerative medicine.