The objective of this chapter is to introduce the cirrhosis. Cirrhosis is scarring of the liver caused by long-term liver damage. The scar tissue prevents the liver working properly. Cirrhosis can eventually lead to liver failure, where your liver stops working, which can be fatal. Three features must be present for calling cirrhosis such as bridging fibrous septae, parenchymal nodules, and disruption of architecture of entire liver. Clinical stages of cirrhosis, pathophysiology, clinical features, macroscopically, microscopy, differential diagnosis, different types of cirrhosis identified on biopsy, staging of cirrhosis, and regression of cirrhosis are also covered in this chapter.