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Chapter-17 Jaundice in Pregnancy

BOOK TITLE: Management of High-Risk Pregnancy—A Practical Approach

Author
1. Raghunandan Chitra
ISBN
9789380704739
DOI
10.5005/jp/books/11228_17
Edition
1/e
Publishing Year
2010
Pages
21
Author Affiliations
1. Lady Hardinge Medical College and SSK Hospital, New, Delhi-83, Lady Hardinge Medical College and SSK Hospital, New Delhi, Lady Hardinge Medical College and Associated Smt SK Hospital, New Delhi
Chapter keywords

Abstract

Jaundice in pregnancy is not uncommon and is the leading indirect cause of maternal mortality in tertiary care centers and it has serious fetal implications. It may be caused by several factors in pregnancy and it needs thorough clinical examination and investigations for accurate diagnosis and treatment. In the developing countries the commonest cause of jaundice is viral hepatitis mostly as a water borne disease due to hepatitis A or E virus. Hepatitis B and hepatitis C is found in endemic areas and are often transmitted by blood and blood products. Improved sanitation, safe drinking water, good personal hygiene and food habits, safe disposal of human excreta are some control measures. Detection of carriers of HBV infection during antenatal period and neonatal immunization is beneficial. Acute fatty liver is peculiar to pregnancy and leads to sudden hepatic failure and high maternal mortality. An intensive care, multidisciplinary approach is needed along with the termination of pregnancy after correction of coagulopathy. Intrahepatic cholestasis of pregnancy is associated with maternal symptoms of intense pruritus and mild jaundice. It carries substantial fetal risks and warrants termination of pregnancy at 37-38 weeks. Preeclampsia is associated with liver dysfunction and HELLP syndrome. Clinical suspicion of liver disease before or after onset of jaundice, early diagnosis of its carriers, prompt referral to higher centers, adequate supportive measures, correction of coagulopathy and whenever required, a prompt decision for termination of pregnancy may go a long way in improving maternal and fetal outcome. Counselling is needed for women regarding future pregnancies.

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