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Chapter-48 Role of LH in Ovarian Stimulation

BOOK TITLE: Principles and Practice of Assisted Reproductive Technology

Author
1. Shetty Nivedita
ISBN
9789352705030
DOI
10.5005/jp/books/18020_49
Edition
2/e
Publishing Year
2019
Pages
8
Author Affiliations
1. Bangalore Assisted Conception Centre Pvt. Ltd. (BACC), # 6 / 7, Kumara Krupa Road, High Grounds, Bengaluru, Bangalore Assisted Conception Center, Reproductive Medicine Apollo Clinic, Mysore, Karnataka, India, Columbia Asia Hospital, Mysuru, Karnataka, India, Columbia Asia Hospital, Mysore, Karnataka, India, Manipal Hospital, Mysore, Karnataka , India, Manipal Hospital, Mysuru, Karnataka, India
Chapter keywords
Luteinizing hormone, follicle-stimulating hormone, in vitro fertilization, ovarian stimulation, gonadotropin theory, LH ceiling, hypogonadotropic hypogonadism, low prognosis women, human menopausal gonadotropin

Abstract

This chapter attempts to understand the rationale behind luteinizing hormone (LH) supplementation during controlled ovarian stimulation, the specific groups that require LH and the various options available for adding LH activity. LH has a really important function in steroidogenesis. It has different roles during the early and the late folliculogenesis, which are explained in this chapter. The LH window is the range of LH level, between the LH threshold and LH ceiling which is when optimal follicular growth occurs. During controlled ovarian stimulation with follicle-stimulating hormone (FSH) only, the endogenous LH is usually adequate to support multiple follicular growth. However, in certain groups, the addition of LH improves the in vitro fertilization (IVF) outcome. The LH activity can be added using gonadotropin preparations like urinary human menopausal gonadotropin (hMG), recombinant LH, and urinary and recombinant human chorionic gonadotropin (hCG).

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