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Chapter-45 Ovulation Trigger

BOOK TITLE: Principles and Practice of Assisted Reproductive Technology

Author
1. Rao Kamini A
2. Rao Vyshnavi A
ISBN
9789352705030
DOI
10.5005/jp/books/18020_46
Edition
2/e
Publishing Year
2019
Pages
9
Author Affiliations
1. Bangalore Assisted Conception Centre, Bangalore, Milann Fertility Centre, Bangaluru, Karnataka, India, Milann—The Fertility Center, Bengaluru, Karnataka, India, Milann (A Unit of BACC Health care Private Limited), Bengaluru, Karnataka, India, Milann (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann (A Unit of BACC, Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann Group of Fertility Centers, Bengaluru, Karnataka, India, Bengaluru, Karnataka, India, Bengaluru, Milann—The Fertility Center (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann—The Fertility Center (A Unit of BACC Health Care Pvt Ltd), Bengaluru, Karnataka, India, Bangalore Assisted Conception Centre, Bangalore, Karnataka, India, BACC Health Care Private Limited, Bengaluru, Karnataka, India, Bangalore Assisted Conception Center (BACC), Bengaluru, Karnataka, India, FOGSI-2001; Bangalore Assisted Conception Center (An ISO 9002 Organization), Karnataka, India, Bangalore Assisted, Conception Centr
2. Milann—The Fertility Center, Bengaluru, Karnataka, India, Milann Fertility Centre, Bengaluru, Karnataka, India, Milann Fertility and Birthing Center, Bengaluru, Karnataka, India
Chapter keywords
Ovulation trigger, ovarian hyperstimulation syndrome, follicle stimulating hormone, human chorionic gonadotropin, oocyte maturation, follicular rupture, intrauterine insemination, in vitro fertilization, recombinant luteinizing hormone, dual trigger, oocyte donor

Abstract

Ovulation trigger is defined as a bioactive preparation which will trigger a cascade of events resulting in the maturation and release of developmentally competent oocyte from a preovulatory graafian follicle. In an ovulatory cycle, luteinizing hormone (LH) surge is caused by estrogen released from preovulatory follicles, which leads to a cascade of reactions. After 36 hours of administration of ovulation trigger, a mature oocyte is released which allows correct timing of intercourse and intrauterine insemination (IUI). Dual trigger enables clinicians to lengthen time between ovulation triggering and oocyte pick up and also simultaneously adding a FSH component causing a FSH surge which can help overcome any impairment in granulosa cell function, oocyte meiotic maturation or cumulus expansion. Kisspeptins are recently discovered peptides which act on kisspeptide neurons located in the anteroventral periventricular nucleus, perventricular nucleus, anterodorsal preoptic nucleus, and pre arcuate nucleus in hypothalamus and are thought to play an important role of GnRH pulse generator in mammals. Advantages and disadvantages of each ovulation triggers are also tabulated in this chapter.

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