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Chapter-13 Luteal Phase Defect

BOOK TITLE: Principles and Practice of Assisted Reproductive Technology

Author
1. Rao Kamini A
2. Sharma Deepti
ISBN
9789352705030
DOI
10.5005/jp/books/18020_14
Edition
2/e
Publishing Year
2019
Pages
10
Author Affiliations
1. Bangalore Assisted Conception Centre, Bangalore, Milann Fertility Centre, Bangaluru, Karnataka, India, Milann—The Fertility Center, Bengaluru, Karnataka, India, Milann (A Unit of BACC Health care Private Limited), Bengaluru, Karnataka, India, Milann (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann (A Unit of BACC, Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann Group of Fertility Centers, Bengaluru, Karnataka, India, Bengaluru, Karnataka, India, Bengaluru, Milann—The Fertility Center (A Unit of BACC Healthcare Pvt Ltd), Bengaluru, Karnataka, India, Milann—The Fertility Center (A Unit of BACC Health Care Pvt Ltd), Bengaluru, Karnataka, India, Bangalore Assisted Conception Centre, Bangalore, Karnataka, India, BACC Health Care Private Limited, Bengaluru, Karnataka, India, Bangalore Assisted Conception Center (BACC), Bengaluru, Karnataka, India, FOGSI-2001; Bangalore Assisted Conception Center (An ISO 9002 Organization), Karnataka, India, Bangalore Assisted Conception Center
2. Milann—The Fertility Center, Bengaluru, Karnataka, India, Rohilkhand Infertility and IVF Center, Bareilly, Uttar Pradesh, India
Chapter keywords
Luteal phase defect, LPD, corpus luteum, CL, Doppler effect, in frozen embryo transfer cycle, donor-recipient cycle, ovarian stimulation cycle, intrauterine insemination, IUI, in vitro fertilization

Abstract

Luteal phase of menstrual cycle starts after ovulation and leads to formation of corpus luteum (CL) which produces progesterone as a major hormone. If pregnancy is not achieved, there is a drop in progesterone levels after failure of CL leading to onset of menses. Luteal phase defect (LPD) is due to insufficient progesterone exposure and inability to maintain secretory endometrium required for embryo implantation. Luteal phase defect leads to dysfunctional endometrial development during the interval when embryo is present in uterine cavity, which in turn leads to impairment of implantation or maintenance of pregnancy. This chapter discusses the incidence and prevalence, physiology of luteal phase, etiopathogenesis of LPD in natural cycles, etiopathogenesis of LPD in controlled ovarian stimulation cycles, diagnosis of luteal phase defect, color Doppler in luteal phase defect, and treatment of luteal phase defect.

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