The objective of this chapter is to introduce the antipsychotics. This chapter covers the history, pharmacokinetics, mechanism of action, indications, principles of therapy, associated medical conditions, first generation antipsychotics, second generation/atypical/dopamine serotonin antagonist antipsychotics, antipsychotic depot preparations, and clinical pearls. Antipsychotics used in treatment of various psychotic disorders including schizophrenia, mania with psychotic symptoms, dementia with delusions, agitation or delusional disorders, delirium secondary to medical conditions. Atypical antipsychotics except clozapine, iloperidone are used in acute mania, in rapidly titrating doses to maximum high dose. Combination of antipsychotic with a mood stabilizer likes lithium or valproic acid is often necessary for a further period after control of symptoms.