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Chapter-08 Adrenergic Drugs

BOOK TITLE: Pharmacology for Medical Undergraduates

Author
1. Bhandari Prasan R
ISBN
9789352702718
DOI
10.5005/jp/books/14244_9
Edition
1/e
Publishing Year
2018
Pages
11
Author Affiliations
1. SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India
Chapter keywords
Adrenergic drug, sympathetic nervous system, adrenergic receptor, catecholamine, noncatecholamine, vasopressor, nasal decongestant, appetite suppressant

Abstract

Adrenergic drugs are also called sympathetic nervous system (SNS). It prepares the body for fright, flight or fight. It is distributed from the thoracolumbar outflow, i.e. T1 to L2–L3. Their ganglia are prevertebral, paravertebral, terminal and adrenal medulla. Major neurotransmitter of SNS includes noradrenaline (NA) and dopamine (DA). A small fraction is metabolized by catechol-Omethyltransferase (COMT) in synapse. Adrenergic receptors were classified by Ahlquist. They are classified into chemical classification, based on mechanism, and therapeutic classification. Catecholamines include adrenaline, noradrenaline, isoprenaline, dopamine, dobutamine, and fenoldopam. Noncatecholamines are devoid of catechol nucleus. They act by direct stimulation of adrenergic receptors and indirectly by releasing noradrenaline (NA). Vasopressors, nasal decongestants, selective β2 stimulants, and anorectics (appetite suppressants) are also discussed in this chapter.

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