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Chapter-73 Antiseptics and Disinfectants

BOOK TITLE: Pharmacology for Medical Undergraduates

Author
1. Bhandari Prasan R
ISBN
9789352702718
DOI
10.5005/jp/books/14244_74
Edition
1/e
Publishing Year
2018
Pages
3
Author Affiliations
1. SDM College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India
Chapter keywords
Nitric oxide, nitric oxide synthase, NOS, nitric acid donor, nitric acid releasor, nitric acid potentiator, nitric acid inhibitor

Abstract

Nitric oxide is also called endothelium-derived relaxing factor (EDRF). It is an unstable free radical gas and catalyzed by nitric oxide synthase (NOS). Three types of NOS are neuronal (nNOS), macrophage or inducible (iNOS), and endothelial (eNOS). Nitric oxide activates guanylate cyclase → formation of cyclic guanosine monophosphate cGMP → decrease in intracellular calcium. A detailed discussion on pathophysiological functions of nitric oxide is presented in this chapter.

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