This chapter presents a glimpse on calcium channel blockers. Calcium channels are of four types i.e. voltage gated, receptor, stretch, and Na+/Ca+2 exchange channel. Voltage-gated calcium channels activated when membrane potential drops to 40 mv. They are of three subtypes, i.e. L, T and N. Entry of extracellular Ca+2 into cardiac and vascular smooth muscle cell through Ca+2 channels leads to release of intracellular Ca+2 from sarcoplasmic reticulum. Pharmacological actions, pharmacokinetics, indications, drug interactions, and adverse effects of calcium channel blockers are discussed briefly in this chapter.