Eye and nose drops are made isotonic to avoid pain or discomfort. Ear drop are formulated as oily solutions to coat and adhere to the aural cavity. Vaginal pessary is the term applied to suppository-shaped medications for vaginal administration. This is a topical treatment and it is important that the drug coats all the vagina mucosa. Vaginal medications whether in pessaries or cream come with applicators which are designed to reach the upper parts of the vaginal canal. Drug administered by nasal or oral respiratory route. Action is either on bronchial tree or systemic due to absorption through lungs, e.g. salbutamol and beclomethasone in bronchial asthma, e.g. drugs are delivered to bronchial musculature in asthma. Aerosols are formed as drug solution or micro-ionized drug powder is converted into mist/dust respectively. A detailed discussion on the new techniques for drug delivery has been provided in this chapter.