Anti-inflammatory drugs are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation. Side effects depend on the specific drug, but largely include an increased risk of gastrointestinal ulcers and bleeds, heart attack and kidney disease. This chapter covers the aceclofenac, acetaminophen, celecoxib, diclofenac sodium, etoricoxib, ibuprofen, indomethacin, nabumetone, ketorolac, tramadol hydrochloride, piroxicam, propoxyphene, sulfasalazine, serratiopeptidase, and chymotrypsin along with their indication, dose, contraindication, precaution, adverse effect, and drug interaction. Ankylosing spondylitis, dental pain, postoperative pain, primary dysmenorrhea, and rheumatoid arthritis are the indications of aceclofenac. Hypersensitivity to aceclofenac or diclofenac, rhinitis, urticaria, asthma, or allergic reactions to aspirin or other anti-inflammatory agents are the contraindications of aceclofenac.