Skin has a special place in psychiatry with its responsiveness to emotional stimuli and ability to express emotions such as anger, fear, shame and frustration, and by providing self-esteem, the skin plays an important role in the socialization process, which continues from childhood to adulthood. The incidence of psychiatric disorders among dermatological patients is estimated at about 30–60%. Psychiatry is more focused on the ‘internal’ nonvisible disease, and dermatology is focused on the ‘external’ visible disease. This chapter covers the body image, classification, cutaneous manifestations of drugs used in psychiatry, management, dermatological manifestations of psychotropic drugs, and miscellaneous issues.