Hormonal contraception is one of the most commonly used contraceptive modalities and provides very good usefulness and low failure rates. The steroid hormone that enables sexual interaction without pregnancy, or with reduced risk of pregnancy, is defined as methods of pregnancy prevention. Progestins are synthetic compounds that imitate the effect of natural progesterone but vary in structure. The COCs contain the same dose of estrogen and progestin administered each day. The other hand, increases the bioavailability of EE, thus erratic intake of vitamin C can result in breakthrough bleeding. The risk is greater in women with hypertension, in smokers, with a family history of migraine, and in women with an extended history of migraine. The OCP should be discontinued 4 weeks before possible major surgery to avoid an increased risk of postoperative thrombosis. The combined contraceptive approved patch is useful to the buttocks, upper outer arm, lower abdomen or upper back avoiding the breast. Progestational contraceptive is also explain about oral progestin only pill, side effect, long-acting methods of contraception, etc.