Diabetes and dyslipidemia are the two major risk factors for atherosclerosis and they increase the risk of cardiovascular diseases. The risk of coronary heart disease (CHD) in patients with diabetes exceeds 20% when compared to nondiabetic patients. Diabetes dyslipidemia is characterized by four features: hypertriglyceridemia, low levels of high-density lipoprotein cholesterol (HDL-C), high proportion of small dense low-density lipoprotein cholesterol (LDL-C) and postprandial lipemia. Non-HDL cholesterol and postprandial triglyceride are also considered as major factor for cardiovascular disease (CVD). The physical activity and proper diet helps to control hypertension and diabetes. High-intensity statin therapy is used to reduce LDL cholesterol levels by more than 50% in the diabetic patients. The lipid lowering agents namely niacin, ezetimibe and fibrates are also helps in maintaining lipid level. The use of these agents may results in some adverse effects such as gastrointestinal disturbances, rash, nausea, headache and pancreatitis.