This chapter discuss about the MOGE(S) Classification of Cardiomyopathy. The systematic use of MOGE(S) provides a large amount of data for national health planning in a short time. The MOGE(S) is a descriptive nosology’s system that includes four major MOGE and one optional S essential descriptors of cardiomyopathies, inherited and noninherited. The M stands for Morpho-functional, which includes hypertrophic cardiomyopathy, restrictive cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy etc., and “O” stands for organ involvement, which include heart and also skeletal muscle, nervous system, liver, kidney etc. And describe the major final cause of failure and death. The descriptor “G” is for genetic Inheritance and describes whether the disease is heritable or not where E stands for Etiology and deals with disease genes and mutations in genetic diseases. In genetic cardiomyopathy the mutations identified, the color codes of device describe possibly and probably pathologic mutations.