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Chapter-103 Central Aortic Blood Pressure as a Prognostic Marker in Hypertension

BOOK TITLE: CSI: Cardiology Update 2014

Author
1. Ram C Venkata S
ISBN
9789351526186
DOI
10.5005/jp/books/12415_104
Edition
1/e
Publishing Year
2015
Pages
6
Author Affiliations
1. Apollo Institute for Blood Pressure Management, Apollo Blood Pressure Clinics, World Hypertension League/South Asia Office, Apollo Hospitals, Hyderabad, Telangana, India, Texas Blood Pressure Institute, Dallas Nephrology Associates, University of Texas Southwestern Medical Center, Texas, USA, Apollo Institute for Blood Pressure Management/Blood Pressure Clinics; Apollo Medical College, Hyderabad, India; Texas, Blood Pressure Institute; Clinical Research and Medical Education, DNA; University of Texas Southwestern Medical Center; American Society of Hypertension Specialists Program; Dallas, Texas, USA, Apollo Institute for Blood Pressure; Apollo Blood Pressure Clinics, World Hypertension League/South Asia Office, Apollo Hospitals, Hyderabad, Telangana, India, Texas Blood Pressure Institute; University of Texas Southwestern, Medical School; Texas, USA, Apollo Institute for Blood Pressure Management, World Hypertension League/South Asia Office, Apollo Hospitals, Hyderabad, Telangana, India; University of Texas, Southwestern Medical School, Dallas, Texas, USA, Apollo Institute for Blood Pressure Management and Apollo Blood Pressure Clinics, Apollo Hospitals, Hyderabad, Telangana, India; World Hypertension League/WHO (South Asia); Hypertension Journal
Chapter keywords
Central aortic pressure, pulse pressure, brachial BP measurements, J-CORE study, ACE inhibitor

Abstract

Measurement form brachial BP does not accurately reflect aortic degenerative changes that are characteristics of cardiovascular disease. Evidence shows that different antihypertensive treatment strategies with similar effects on brachial BP may have diverse effects on central aortic pressure (CAP). CAP represents the BP actually perceived by the heart and brain and is therefore predictive of cardiovascular outcomes. Reduction in BP and/or an increase in vascular compliance are associated with a reduction in cardiovascular risk. Studies have highlighted central and brachial BPs are helpful in predicting cardiovascular risk and clinical outcomes. CAP is determined by cardiac output and peripheral vascular resistance. CAP can be estimated by SphygmoCor. Therapeutic effect of antihypertensive drugs based on central and peripheral BP levels are discussed.

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