EXPORT CITATION

Chapter-53 Ischemia Reperfusion

BOOK TITLE: Kidney & Pancreas Transplantation

Author
1. Giangola Matthew
2. Rajayer Salil
3. Kuncewitch Michael
4. Khader Adam
5. Wang Ping
ISBN
9789351523390
DOI
10.5005/jp/books/12547_54
Edition
1/e
Publishing Year
2015
Pages
4
Author Affiliations
1. Feinstein Institute for Medical Research, North Shore-LIJ Health System, Hempstead, New York, USA
2. Woodhull Medical and Mental Health Center, New York University School of Medicine, New York, USA
3. Feinstein Institute for Medical Research, North Shore-LIJ Health System, Hempstead, New York, USA
4. Feinstein Institute for Medical Research, North Shore-LIJ Health System, Hempstead, New York, USA
5. North Shore-LIJ Health System, Center for Translational Research, The Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, Hempstead, New York, USA
Chapter keywords
Renal ischemia/reperfusion injury (renal I/R), pathophysiological mechanisms, inflammatory cells, reactive oxygen species (ROS), reactive nitrogen species (RNS), intracellular homeostasis, cell death, antioxidant enzymes, hormonal mediators

Abstract

Renal ischemia/reperfusion injury (renal I/R) involves several complex pathophysiological mechanisms that are incompletely understood. An accumulation of inflammatory cells and mediators, reactive oxygen species (ROS), and reactive nitrogen species (RNS) comes with the return of blood flow. The subsequent biochemical derangements in intracellular homeostasis together work to induce further cell death from inflammation, apoptosis, and necrosis. Animal experimental models of renal I/R injury have allowed investigators to focus on a number of important basic mechanisms involved in the regulation of renal function. Future therapeutic considerations and targets renal ischemia reperfusion include: antioxidants and antioxidant enzymes, hormonal mediators and nitric oxide mediators.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved