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Chapter-02 History of Thrombolysis

BOOK TITLE: Textbook of Cardiology (A Clinical & Historical Perspective)

Author
1. Chopra HK
2. Sambi RS
3. Krishna CK
ISBN
9789350900819
DOI
10.5005/jp/books/12259_2
Edition
1/e
Publishing Year
2013
Pages
5
Author Affiliations
1. Moolchand Medcity Hospital, New Delhi, India, Medanta Moolchand Heart Institute, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity, New Delhi, India, Medanta Moolchand Heart Institute, Moolchand Medcity; World Wellness Foundation, WHA; AHA, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA; CSI & IAE; IHJ, JIAE, Medanta Moolchand Heart Institute; Moolchand Medcity; World Wellness Foundation, WHA, Medanta Moolchand Heart Institute, New Delhi, India; CME, Moolchand Medcity, World Wellness, Foundation and WHA; AHA; CSI and IAE; IHJ and JIAE, IAE-2017, CSI-2015; World Wellness Foundation, Country Head, American Heart Association; Medanta Moolchand Heart Institute; Health Committee, SCOPE, Tata Sky FAM Health, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; American Heart Association; Moolchand Medcity; Physician Governing Body, CME, COP Moolchand Medcity, New Delhi, India, IAE- 2017, CSI -2015; World Wellness Foundation; Physician Governi
2. National Heart Institute, New Delhi, India
3. Moolchand Medcity, New Delhi, India
Chapter keywords
physiological thrombosis, hemostatic, macroscopic vascular injury, intrinsic antithrombotic properties, fibrinolysis, thrombo-embolic phenomena, thrombolytic therapy

Abstract

Physiological thrombosis is an important part of the normal hemostatic response that limits hemorrhage caused by microscopic or macroscopic vascular injury. This is counterbalanced by intrinsic antithrombotic properties and fibrinolysis. However, under pathological conditions, a thrombus can partially or completely obliterate a vessel lumen or propagate into an otherwise normal vessel. Over the last century, thrombolytic therapy has gained prominence in the management of thrombo-embolic phenomena and has helped hundreds of physicians in reanalyzing cardinal vessel occlusions. This chapter reviews major milestones in the history of thrombolysis. Streptokinase, urokinase, alteplase, tenecteplase are discussed under development of thrombolytic therapy. Advantages of newer agents over the older agents and trends in thrombolysis are described.

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