This chapter provides detail description of Kawasaki disease. Chapter has 4 well illustrated diagrams and pictures. Kawasaki disease, Causes of Kawasaki disease, classical Kawasaki disease, atypical Kawasaki disease, vaccination in Kawasaki disease, sign and symptoms, acute febrile stage, sub-acute stage, convalescent stage, investigations, treatment, complications, treatment of complications and prognosis are described in detail. 29 references are included at the end of the chapter to facilitate further reading.