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Chapter-13 Plasma Proteins

BOOK TITLE: Textbook of Biochemistry for Dental Students

Author
1. Vasudevan DM
2. S Sreekumari
3. Vaidyanathan Kannan
ISBN
9789350254882
DOI
10.5005/jp/books/11333_13
Edition
2/e
Publishing Year
2011
Pages
6
Author Affiliations
1. Faculty of Medicine, Amrita Vishwa Vidyapeetham, (Amrita University), Kochi, Kerala, Formerly Principal, College of Medicine, Amrita, Kerala; Formerly, Dean, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, Amrita Vishwa Vidyapeetham (Deemed University), Cochin, Kerala, E-mail: dmvasudevan@aims.amrita.edu, PG Programs and Research College of Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India, College of Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India; Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
2. Jubilee Mission Medical College, Trissur, Kerala, Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India, Government Medical College, Thrissur and Thiruvananthapuram, Kerala, India; Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India; Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India
3. Amrita Institute of Medical Sciences, Kochi, Kerala, India, Pushpagiri Institute of Medical Sciences and Research Centre, Thiruvalla, Kerala, India, Believers Church Medical College and Hospital, Thiruvalla, Kerala, India
Chapter keywords

Abstract

Total protein content of plasma is 6–8 g/dl. Plasma albumin content is 3.5–5 g /dl. Plasma globulin content is 2.5–3.5 g /dl. Plasma proteins are separated by electrophoresis, where albumin, alpha-1, alpha-2, beta and gamma fractions are seen. Albumin has the maximum anodal mobility. Functions of albumin are: (a) it maintains the colloidal osmotic pressure of plasma and (b) it carries bilirubin and non-esterified fatty acids. When albumin level is below 2 g/dl, edema results. Hypoalbuminemia is seen in cirrhosis, malnutrition and nephrotic syndrome. Albumin is synthesized in liver; hence plasma albumin level is an important liver function test. Ceruloplasmin contains copper; it is decreased in Wilson\'s hepato lenticular degeneration. Blood fibrinogen level is 200– 400 mg / dl. Hemophilia is due the deficiency of anti hemophilic globulin (AHG) or factor VIII. Immunoglobulins are classified into 5 classes; IgG, M, A, D, and E. IgM is seen in primary antibody response. IgA is secretory antibodies. IgE is associated with allergy and anaphylaxis.

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