Most of the epidemiological information is available from developed countries of Northern America, Europe and Australia, which constitute only about 20% of the world population. Since epidemiology varies from region to region, there is a need to have specific epidemiological information from the developing countries of Asia, Africa and Latin America in order to devise cost-effective, region-specific primary prevention programs. The global estimate of SCI incidence ranges between 8.0 and 83.0 per million per year. Available literature from Australia, Finland, Sweden and US reveals that prevalence ranges from 280 to 755 per million per population. However, due to the lack of data from other regions, worldwide estimate can’t be made. Most persons who sustain SCIs are males in their late teen or 20s and are not married. These persons are most often injured in road traffic accidents or falls. The incidence of injuries due to violence has been increasing. There have been many interesting changes in trends in the demographics and etiologies of SCIs with time. The incidence of SCI in geriatric population and in female gender is gradually increasing with time. The proportion of tetraplegics has gradually reduced and a similar trend has been noted for neurologically incomplete injuries.