This chapter provides detail description of Tuberculosis of spine. Chapter has 14 well illustrated diagrams and pictures. Spinal tuberculosis, pathology and pathogenesis, route of infection of spinal diseases, types of lesions involved in spinal tuberculosis, neurological involvement in spinal tuberculosis, clinical presentation of spinal tuberculosis, imaging in spinal tuberculosis, magnetic resonance imaging in spinal tuberculosis, radioisotopes bone scans, treatment of spinal tuberculosis, posterior spinal fusion, excisional therapy and grafting, recent trends in management of spinal tuberculosis, late onset of paraplegia, correction of kyphosis, indications of surgical therapy and craniovertebral tuberculosis are given in detail. 178 references are included at the end of the chapter to facilitate further reading.