This chapter has well written text and 9 well illustrated diagrams showing diffuse axonal injury. Incidence, pathogenesis of diffuse axonal injury along with clinical presentation are given in detail. Investigations in a case of diffuse axonal injury are described with the help of diagrams and radiographic pictures. Management, prognosis and postoperative complications of diffuse axonal injury are described at the end of the chapter. 50 references are given for further reading to conclude this chapter.