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Chapter-29 Anti-Vascular Endothelial Growth Factor Therapy

BOOK TITLE: Clinical Ophthalmology: Medical and Surgical Approach

Author
1. Kumar Atul
2. Sinha Subijoy
ISBN
9789350250044
DOI
10.5005/jp/books/11246_29
Edition
2/e
Publishing Year
2011
Pages
10
Author Affiliations
1. Dr. RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, All India Institute of Medical Sciences New Delhi, India, Anil Hospital, Jaipur, India, Dr RP Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Jaipur, Rajasthan, India, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, Women’s Health Center; Anil Nursing Home, Jaipur, Rajasthan, India, All India Institute of Medical Sciences, New Delhi, India
2. Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India, All India Institute of Medical Sciences New Delhi, India
Chapter keywords

Abstract

Michaelson first suggested that a diffusible “Factor X” from the retina stimulated the retinal and iris neovascularization seen in diabetic retinopathy. Two decades ago, a molecule was identified in the conditioned media from bovine pituitary follicular cells that promoted the proliferation of endothelial cells and was called vascular endothelial growth factor (VEGF). In 1992, it was demonstrated that hypoxia could up-regulate VEGF expression. It had long been appreciated that neovascularization of the retina and iris is related to retinal ischemia due to various etiologies, and the property of hypoxia inducibility made VEGF a plausible candidate for the “Factor X,” proposed by Michaelson, as the mediator of abnormal blood vessel growth in the eye. Evidence from both clinical and animal studies accumulated in the next several years to support the critical role of VEGF in ocular neovascularization.

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