Current investigations for retinal diseases are: (i) Fluorescein angiography: Novotny and Alvis performed the first successful fluorescein angiography in humans by using digital imaging technique. Our understanding on fluorescein angiography is still expanding. (ii) Indocyanine green angiography: Digital indocyanine green angiography is useful in imaging the choroid and its associated pathology. Indocyanine green is a tricarbocyanine dye that has several special properties, which gives it an advantage over sodium fluorescein, as a dye for ophthalmic imaging. (iii) Optical coherence tomography: Is a new technique for the high resolution, cross-sectional visualization of retinal structure. Optical coherence tomography achieves 2 or 3 dimensional cross-sectional imaging of retina by measuring the echo delay and intensity of back reflected infrared light from internal tissue structures. (iv) B-scan ultrasonography: Ultrasound examination is indicated when opacification of the ocular media precludes adequate clinical examination of the posterior segment. In the presence of clear media, it is useful for evaluation of the state and position of the vitreous. (v) Microperimetry: Automated full threshold static perimetry has been established in clinical practice to reveal and quantify functional defects of the visual field. It is difficult to obtain adequate evaluation in patients with macular disease because of unstable fixation. (vi) Multifocal electroretinography: The electroretinogram is an electrical potential generated by the retina in response to a flash of light. It is an excellent tool for studying retinal function independently. All useful information regarding the diagnosis, management and follow up in retinal diseases.