Congenital fetal infection commonly refers to transplacentally acquired infection from the infected mother, that and can occur at any time during pregnancy, also during vaginal delivery, via breast milk, by exposure in the neonatal period. Infections in the pregnant woman are being recognized as an important cause of fetal and neonatal mortality and morbidity. Maternal infections may be symptomatic, mild or symptomless and may not always result in fetal infection. TORCH serology should be well understood so that unnecessary interventions or even termination of completely healthy baby can be avoided. The first trimester is usually the most dangerous time for the mother to acquire these infections, because there is a greater risk of the fetus being affected. Congenital fetal infection may be of varying severity and extent of organs affected. Seriousness of fetal damage depends on: period of gestation at attack, severity/load of maternal infection, immune status of mother and early institution of maternal-fetal therapy. Prevention of congenital infection by prenatal screening, and application of molecular and serological assays to case based investigations is important. Rubella is on the verge of elimination, and new challenges for control and prevention include Preconception health care, improved vaccination and perinatal infection prevention practices among obstetrician-gynecologists.