This chapter discussed on biologic considerations in restorative procedures. Re-establishment of health of teeth by restorative means depends on the mode of treatment initiated, how it is carried out and degrees of result occur. Consideration to this biologically related factors during restoration will maximize tooth health with a healthy oral environment. Biological response to cutting procedures depends on: 1. Depth of cavity preparation and the extend of preparation (R). 2. Heat production during cutting. 3. Pressure on cutting can cause heal production leading to coagulation of protoplasm and dentine problem. 4. Speed of rotation. 5. Coolants. 6. Nature of cutting instruments. 7. Size of burs of wheels also affect the pulpal response. 8. Vibration employed or vibration of instruments. 9. Personal variation like age of the patient, condition of pulp, etc.