EXPORT CITATION

Chapter-31 Antiangiogenic Agents in Endometriosis

BOOK TITLE: Endometriosis: Current Management and Future Trends

Author
1. Novella-Maestre Edurne
2. Pellicer Antonio
ISBN
9788184488081
DOI
10.5005/jp/books/11032_31
Edition
1/e
Publishing Year
2010
Pages
11
Author Affiliations
1. Valencia University, Valencia, Spain
2. Instituto Universitario IVI, Valencia University, Valencia, Spain, Instituto Valenciano de Infertilidad, Valencia, Spain, Yale University, USA; IVIRMA; University Medical School, Valencia; University Medical School, Valencia; Polytechnic University, Valencia; Fertility and Sterility
Chapter keywords

Abstract

Endometriosis, defined as the presence of functional endometrium, composed of glands and stroma, outside the uterine cavity, is a common benign disease, causing abdominal pain, dysmenorrhea and dyspareunia in about 10–15% of all women in reproductive age and more than 30% of women attended in infertility clinics. There are a number of theories to explain how endometriosis occurs. Out of them, the implantation theory of Sampson (1927) is the most widely accepted. According to Sampson,, the endometrial tissue is retrogradely shed through the Fallopian tubes into the peritoneal cavity, where it attaches and proliferates at ectopic sites during menstruation. However, endometriosis is a condition showing congenital tendencies and a polygenic/multifactorial etiology has been suggested. The cause for the adherence of the eutopic endometrium in ectopic locations remains unknown in these patients. In addition there are several factors like etiopathogenic, genetic, environmental, hormonal, immunologic, oxidative stress and growth factors which are implicated in the establishment, development and maintenance of endometriosis.

Related Books

© 2019 Jaypee Brothers Medical Publishers (P) LTD.   |   All Rights Reserved