The chapter starts off with materials used for pulp capping, root canal filling or obturation, Gutta percha. Then chapter explains about root canal sealers, different types of sealers and requirements of different sealers. The section finishes off with explaining about clinical aspects of endodontic materials like biocompatibility issues and physical properties. The next section starts with discussion about post and core and various different types of posts employed. Last section deals with root canal instruments its classification, standardization, various individual instruments like files, reamers, broaches, rasps. The section also deals with mechanical root canal instruments like gates glidden drill, peeso reamers and nickel titanium instruments.