The liver is the largest organ in the body weighing 1400-1600 gm in the males and 1200-1400 gm in the females. The right and left lobes of the liver are separated anteriorly by a fold of peritoneum called the falciform ligament, inferiorly by the fissure for the ligamentum teres, and posteriorly by the fissure for the ligamentum venosum. The blood supply to the liver parenchyma flows from the portal triads to the central veins. Bilirubin pigment can be detected in serum, faeces and urine. The liver plays a central role in carbohydrate metabolism. Jaundice is the result of elevated levels of bilirubin in the blood termed hyperbilirubinaemia. Hereditary non-haemolytic hyperbilirubinaemias are a small group of uncommon familial disorders of bilirubin metabolism when haemolytic causes have been excluded. Biliary atresias, also called as infantile cholangiopathies, are a group of intrauterine developmental abnormalities of the biliary system. Amoebic liver abscesses are less common than pyogenic liver abscesses and have many similar features. They are caused by the spread of Entamoeba histolytica from intestinal lesions. The gallbladder is a pear-shaped organ, 9 cm in length and has a capacity of approximately 50 ml. It consists of the fundus, body and neck that taper into the cystic duct.