This chapter discusses management of larynx and hypopharynx cancer, where genotypic and phenotypic deficiencies in the metabolism of tobacco-related and other carcinogens as well as abnormalities in DNA repair mechanisms may also be involved in the predisposition to laryngeal and pharyngeal cancers. High rates of larynx and hypopharynx cancers correlate with poor intake of fruits, vegetables, vegetable oil, fish and with high intake of butter and preserved meat. The larynx is the portion of the respiratory tract between the oropharynx and the nasal cavities and the trachea. The supraglottic larynx is made of the superior margin of the larynx, the epilarynx, and the laryngeal vestibule. The subglottic larynx is limited superiorly by the inferior face of the true vocal cord and, inferiorly, by the superior limit of the trachea. The inferior segment of the aerodigestive tract, the hypopharynx or low pharynx, is the portion of the pharynx between the oropharynx and cervical esophagus.