This chapter discusses pathology, where malignant tumors comprise greater than 70 percent of sublingual tumors, 40-50% of submandibular gland tumors, 50 percent of minor salivary gland tumors and 20-30 percent of parotid tumors. The salivary glands are composed of lobules of acinar tissue separated by thin fibroconnective tissue. The lymphoid component is composed of predominantly small lymphocytes, frequently associated with germinal centers. Myoepitheliomas represent the opposite end of the spectrum of monomorphic adenomas being composed exclusively of myoepithelial cells in contrast to the predominant ductal epithelial proliferation of BCA. Cystadenomas of the major salivary gland have the typical clinical presentation of a slow growing mass in a middle-aged female. A larger proportion of malignant tumors occur in the minor salivary glands as opposed to the major glands. Three cell types are needed to establish the diagnosis, such as mucous cells, squamous cells and intermediate cells.