This chapter discusses reconstruction of facial mohs defects, where most important carcinogenic wavelengths for the induction of skin cancer come from ultraviolet B (UVB) light, although ultraviolet A (UVA) has also been implicated. Cryotherapy can also be used for low-risk lesions, and involves the application of liquid nitrogen. For high-risk lesions, Mohs micrographic surgery remains the standard of care. Mohs surgery goes by several different names, such as Mohs chemosurgery, Mohs micrographic surgery, and microscopically oriented histologic surgery (MOHS). The basic tenet of Mohs surgery is the ability to review 100 percent of the peripheral and deep margins, thus maximizing tumor control. The Mohs procedure is performed under local anesthesia in an outpatient setting. Mohs surgery is an excellent technique which should be used whenever possible for high-risk lesions, providing an unparalleled cure rate, even for recurrent tumors.