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Chapter-05 Sickle Cell Screen — Metabisulphite

BOOK TITLE: Laboratory Procedures in Haematology

Author
1. Mehdi SR
ISBN
9788180616570
DOI
10.5005/jp/books/10437_5
Edition
1/e
Publishing Year
2006
Pages
2
Author Affiliations
1. JN Medical College, AMU, Aligarh, India, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India
Chapter keywords

Abstract

If the solubility test for haemoglobin S does not produce result then the other screening test known as the Sodium Metabisulphite test is employed. The test is based on the principle that sodium metabisulphite, a reducing agent deoxygenates blood and the haemoglobin S carrying, otherwise normal looking RBC start sickling in a hypoxic state.

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